Types of headache and migraine

The classification and diagnosis of headache disorders

Given the wide range of different headache and migraine types, systematically classifying and diagnosing them have been deemed essential to aid proper clinical management.² The third edition of the ICHD is the current standard for headache classification and diagnosis.¹ The classification of headache types is hierarchical, and a detailed diagnosis requires navigating the diagnostic criteria of the subtypes and subforms.¹ Additionally, a detailed history of the patient’s headache is crucial for forming a correct diagnosis.³ This should include details such as headache frequency, duration, character, severity, location, quality, triggering and aggravating factors, alleviating features, and age of onset. Additional details such as lifestyle habits and comorbid conditions, or underlying medical disorders, are also useful for aiding a diagnosis.³

While the symptoms and features of different headache types vary, there is also significant overlap among them, making an exact diagnosis a challenge. Moreover, patients can experience different headache types, which necessitates multiple diagnoses.¹ To make matters even more difficult, a headache’s symptoms, pain intensity, and duration can vary greatly, even within the same patient.

Headache types

There are two main categories of headache disorders: primary headaches and secondary headaches.¹ While a primary headache is a disorder of its own, a secondary headache is only a symptom of an underlying condition. Primary headaches can be further categorized into 4 main types: 1) migraine, 2) tension-type headache (TTH), 3) trigeminal autonomic cephalalgias (TACs) such as cluster headache, and 4) other primary headache disorders.¹

Meanwhile, secondary headaches can be attributed to events like trauma or injury, cranial or vascular disorders, infection, or substance use such as medication-overuse headache (MOH).¹

Primary headaches constitute the large majority of all headache disorders (more than 95%), of which tension-type headache is the most common (Figure 1).⁴ According to the World Health Organization (WHO), the most common secondary headache is MOH.⁵

Primary headaches

Primary headaches—TTH and migraine in particular—are extremely prevalent and a huge burden to society.^7,8 Although TTH is more common than migraine, the greater disability weight of migraine gives it a higher years lived with disability (YLD) score compared to TTH.^7,8 In fact, migraine has been ranked as the leading cause of disability (measured in YLD) among individuals aged 15–49 years.⁷

MIGRAINE

The two major types of migraine are migraine without aura (formerly called common migraine) and migraine with aura (also called classic migraine).¹ Attacks of migraine without aura usually last 4–72 hours. Typical features include unilateral, pulsating headache of moderate to severe intensity associated with nausea, vomiting, and sensitivity to light, sound or smell.¹ Migraine with aura starts with aura symptoms preceding the actual headache, lasting up to one hour.¹ Both of these migraine types are characterized as episodic migraine, based on the number of headache days per month. If a migraine occurs on 15 or more days per month for more than three months, it is instead classified as chronic migraine.¹ Although chronic migraine is less common than episodic migraine—affecting approximately one tenth of all migraineurs—it is extremely disabling and severely impacts the patient’s quality of life.⁹

TENSION-TYPE HEADACHE (TTH)

TTH is typically not as severe as migraine.³ It is often a dull, bilateral, mild-to-moderate headache pain without other striking features.³ The infrequent episodic form of TTH is thought to be experienced by almost everyone at one point or other, and generally does not require any medical attention.¹ Frequent episodic TTH, on the other hand, is more disabling and may warrant medication, whereas the rarer chronic TTH is severely disabling, usually leading to a greatly decreased quality of life.¹

TRIGEMINAL AUTONOMIC CEPHALALGIA (TAC)

TACs are a group of primary headaches that share the clinical features of a unilateral headache and are often associated with ipsilateral cranial autonomic features.³ The most common TAC is cluster headache, characterized by clusters of severe attacks that last between 15 min and 3 hours, occurring daily for a few weeks up to a few months.³ The remission period between these clusters can last several months to years.¹ Cluster headache, for unknown reasons, affects three times more men than women.¹ Other TACs include paroxysmal hemicrania, short-lasting unilateral neuralgiform headache attacks, and hemicrania continua.¹

Secondary headaches

Unlike primary headaches, secondary headaches are symptoms of underlying conditions or attributed to external factors such as injury, cranial or vascular disorders, infection, or substance use.¹ Although secondary headaches are uncommon, diagnosing them is important, as timely intervention can be crucial for treating a potentially fatal underlying condition.⁴ Usually, patients with secondary headaches will have ‘red flag’ symptoms in their patient history that should aid in forming the diagnosis.⁴

MEDICATION-OVERUSE HEADACHE (MOH)

MOH, also known as drug-induced headache or rebound headache, is a type of secondary headache associated with regular overuse of headache medication, and usually develops secondary to a pre-existing headache syndrome that is being treated with medication.¹ Virtually all types of headache medication can lead to MOH.⁶ It has been suggested that MOH has a genetic component.⁶ Due to a lack of large-scale studies, more research is needed to draw conclusive results.⁶ Managing MOH is not completely straightforward, as medication withdrawal may not always improve outcomes, instead sometimes even leading to unanticipated negative outcomes.³ However, research suggests that complete withdrawal of the medication that causes MOH is generally more effective than just simply restricting its intake.¹⁰